Sequence census methods couple high-throughput DNA sequencing to biochemical assays and are transforming standard functional genomics assays into powerful

genome-wide probes of biochemical activity. At the heart of these methods is a reduction from biochemistry to computation. We will survey the plethora of *-Seq assays that have been developed and discuss how information theory serves the dual role of helping in design of the assays and the interpretation of experiments.

Presented at the UC Berkeley - New Directions in the Science of Information